The influence of air inside the media on Tablet Dissolution Test results

Non-de-aerated media significantly affects the outcomes of a tablet dissolution test. For instance, they can enhance the Prednisone release rate by up to 50% compared to using properly de-aerated media. In the images below, a Prednisone Test is displayed, with both images captured after 10 minutes. The left image shows de-aerated media, with no floating particles present. In contrast, the right image shows non-de-aerated media, leading to a higher release rate due to floating particles and a reduced tablet cone.

PT-DDS4 Media Preparation and Degassing System from Pharma Test AG Germany, prepares dissolution media by degassing or “de-aeration”, pre-heating to a temperature of 37°C and absolutely precise gravimetric dispensing according to the recommendations and demanded for dissolution testing from the US FDA authorities.

De-aeration is generally recommended to prevent the formation of bubbles on the dosage form surface, which may cause a variation in active dissolution rates, by virtue of surface obscuration